Resveratrol Red Wine Extract Product Review

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Types of Resveratrol
Resveratrol can be found naturally in two types (isomers). Trans-Resveratrol is the most biologically active and is preferable for purposes of supplementation. Be sure to check the label of your supplement and verify that the amount of trans-Resveratrol is specified. Trans-Resveratrol oxidizes into cis-Resveratrol. Cis-Resveratrol is less biologically active. Resveratrol oxidizes from "trans" to "cis" forms quickly so choosing a manufacturer that protects the integrity of the compound against oxidation is important. Protection methods include cold storage of the bulk herb or compound. The type of capsule and the delivery mechanism is also important. Leading manufacturers use air-tight capsules with a nitrogen bubble inside each capsule to protect the Resveratrol compound from oxidation. Capsugel's Licaps are a good example of a sealed protective capsule that's used for some preparations. Trans-resveratrol is quickly metabolized in the digestive system so it may also be mixed with other compounds to increase absorption or keep the compound active in our systems for as long as possible. Most commercially available forms come from a plant called Japanese Knotweed (polygonum cuspidatum). This produces the same molecule that is found in grapes and red wine.

What are the benefits of taking Resveratrol?
Purported benefits include blood sugar lowering, anti-inflammatory , increased endurance, improved complexion, cancer fighting and longevity to name a few. Early experiments significantly extended the lifespan of yeast, worms and fruit flies. One of the most publicized experiments tested mice that were fed a high fat diet and supplemented with Resveratrol with mice fed a standard diet. The addition of trans-Resveratrol counteracted almost all of the negative affects of the high fat diet. Mice fed the high fat diet had a 30% lower risk of death than mice fed the standard diet.

In vitro test have shown Resveratrol has positive effects in counteracting a number of human cancers however, not enough is known to determine if Resveratrol would work to prevent cancer systemically in vivo. Studies indicate that very high and potentially unsafe levels of the compound may be required for systemic cancer prevention. No in-vivo human tests have been completed to test red wine extract's effectiveness as a cancer fighting or preventative treatment.

How does Resveratrol work?
Resveratrol is thought to activate the Sirtuin 1 (SIRT1) gene in humans. SIRT1 is normally activated during states of extreme caloric restriction and is linked to cell longevity. Resveratrol is also linked to a reduction in superoxide, a potent contributor to free radical reactions and thereby may increasee the bodies defense against a number of diseases including cancer. Resveratrol is also a potent antioxidant. Additionally, at least one study links the compound with maintaining telomere lengths which is thought to be a key component in delaying and possibly reversing aging. Again, no in-vivo human testing has validated these results.

How much should I take?
The FDA has issued no guidelines on the use of Resveratrol. Consumption is primarily experimental. Based on early studies with mice, some individuals were taking as much as 5-7 grams a day. More recent studies with mice show benefits with a lesser dose, which translates to between 20MG and 500MG per day for a human. More studies are required to determine safe and effective dosage levels.

Some studies also indicate that the spectrum of compounds (polyphenols) in red wine are more beneficial than resveratrol alone. That has prompted some manufacturers to combine the compound with other synergistic ingredients such as quercitin, a natural bioflavinoid, ferulic acid, IP6 and potentially other ingredients to mimic the benefits of resveratrol in wine but at levels that would be difficult to achieve by drinking wine alone.

Are there side effects?
Resveratrol side effects are thought to be minimal. Studies have identified a phytoestrogenic effect with Resveratrol which may interfere with contraceptives. Studies are mixed on the effect of Resveratrol on breast cancer with one study linking the phytoestrogenic nature of Resveratrol with breast cancer. Another study has shown the potential inhibitory effect against breast cancer. Overall, Resveratrol appears to be safe however, a physician should be always consulted before beginning a Resveratrol regimine.